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Winald Gerritsen of the Radboud University Nijmegen Medical Centre in the Netherlands, noted that although the study did not meet its primary endpoint, there is 鈥渁 suggestion of greater activity in those with less advanced CRPC鈥? He claimed that 鈥渢hese results offer important insights for ongoing and future studies of Yervoy in prostate cancer鈥? including an ongoing second large trial in patients with less advanced disease.